WARDS NATURAL SCIENCE ESTABLISHMENT INC -- CAFFEINE -- - 
=====================  Product Identification  =====================

Product ID:CAFFEINE
MSDS Date:10/05/1992
FSC:NIIN:Submitter:D DG
Status Code:A
=== Responsible Party ===
Company Name:WARDS NATURAL SCIENCE ESTABLISHMENT INC
Address:5100 W HENRIETTA RD
Box:92912
City:ROCHESTER
State:NY
ZIP:14692
Country:US
Info Phone Num:(716) 359-2502 OR 800-962-2660
Emergency Phone Num:(800)424-9300
Resp. Party Other MSDS Num.:CC 25
Chemtrec Ind/Phone:(800)424-9300
CAGE:63759
=== Contractor Identification ===
Company Name:WARDS NATURAL SCIENCE ESTABLISHMENT INC
Address:5100 W HENRIETTA RD
Box:92912
City:ROCHESTER
State:NY
ZIP:14692-9012
Country:US
Phone:(716) 359-2502
Contract Num:MDA414-99-A-0024-0087
CAGE:63759

=============  Composition/Information on Ingredients  =============

Ingred Name:1,3,7-TRIMETHYLXANTHINE
CAS:58-08-2
RTECS #:EV6475000
= Wt:100.

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:LD50 ORAL MOUSE 127MG/KG.
Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:INGESTIN AND INHALTION:NO TLV
    ESTABLISHED. MAY ACT AS STIMULANT IF EXCESSIVE INGESTION. LARGE
    DOSES (ABOVE 1G) MAY CAUSE PALPITATION, EXCITEMENT, INSOMNIA,
    DIZZINESS, HEADACHE AND VOMITING. SKIN AND E YES:AS DUST OR VAPOR
    MAY BE AN IRRITANT. EXERCISE APPROPIRATE PROCEDURES TO MINIMIZE 
    POTENTIAL HAZARDS.
Effects of Overexposure:MAY ACT AS A STIMULANT IF EXCESSIVE INGESTION.
    LARGE DOSES (ABOVE 1 G) MAY CAUSE PALPITATION, EXCITEMENT,
    INSOMNIA, DIZZINESS, HEADACHE AND VOMITING. AS DUST OR VAPOR MAY BE
    AN IRRITANT. EXERCISE APPR OPRIATE PROCEDURES TO MINIMIZE POTENTIAL
    HAZARDS.

=======================  First Aid Measures  =======================

First Aid:INGESTION:IF SWALLOWED, IF CONSCIOUS,GIVE 1 OR 2 GLASSES OF
    WATER TO DRINK,INDUCE VOMITING AND CALL PHYSICIAN. NEVER GIVE
    ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON. SKIN:FLUSH WITH WATER,
    THEN WASH W ITH MILD SOAP AND WATER. EYE:FLUSH THOROUGHLY WITH
    WATER LIFTING UPPER AND LOWER EYELIDS OCCASIONALLY. IF IRRITATION
    DEVELOPS OR PERSISTS GET MEDICAL ATTENTION. INHALATION:REMOVE TO
    FRESH AIR. IF ILLN ESS OR DISCOMFORT DEVELOPS GET MED ATTN.

=====================  Fire Fighting Measures  =====================

Autoignition Temp:=925.C, 1697.F
Lower Limits:2G/CU FT
Upper Limits:16G/CU FT
Extinguishing Media:USE ANY MEDIA SUITABLE FOR EXTINGUISHING SUPPROTING
    FIRE.
Fire Fighting Procedures:IN FIRE CONDITIONS, WEAR NIOSH-APPROVED
    SELF-CONTAINED BREATHING APPARATUS AND FULL PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:WHEN HEATED TO DECOMPOSITION, EMITS TOXIC
    FUMES OF NITROUS OXIDES AND OTHER HAZARDOUS MATERIALS;CAN REACT
    VIGOROUSLY WITH OXIDIZING MATERIALS. SEVERE (BUREAU OF MINES
    EXPLOSION HAZARD RATINGS)AS DUST.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR PROTECTIVE SAFETY EQUIPMENT AND USE
    ADEQUATGE VENTILATION. AVOID MAKING DUST. SWEEP UP AND PLACE IN
    SUITABLE CONTAINER FOR DISPOSAL. FLUSH SPILL AREA WITH WATER. DO
    NOT ALLOW WASH WATER TO POLLUT E WATER WAYS AND STREAMS. RECOVER
    FOR USE IF NOT CONTAMINATED.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN COOL DRY PLACE.WASH WELL AFT
    HNDL.AVOID BREATH DUST/VAP.DONT INGEST.REMOVE & WASH CONTAM
    CLOTH.KEEP CNTNR TIGHTLY CLSD WHEN NOT IN USE.READ LABEL ON CNTNR
    BEF USING. DONT WEAR CONTACT LENSES  WHEN WORKING W/CHEMS.FOR LAB
    USE ONLY.NOT FOR DRUG/FOOD/ HOUSEHOLD USE.KEEP OUT OF REACH OF
    CHILDREN
Other Precautions:FDA HAS RECENTLY PROPOSED REMOVEAL OF CAFFEINE FROM
    ITS "GENERALLY RECOGNIZED AS SAFE"LIST & IS GATHERING ADDTN
    INFO.CONCERNS W/EXCESSIVE USE INCLUDE POSSIBLE REPRODUCTIVE EFFECTS
    TO FETAL CRANIOFACIA L AREA, MUSCULOSKELETAL SYSTEM,POSSIBLE
    BLADDER CANC(2 SEPARATE EPIDOMIOLOGICAL STUDIES)(CONTD OTHER  INFO
    SEC)

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:NONE SHOULD BE NEEDED IN NORMAL LABORATORY
    HANDLING. IF DUSTY CONDITONS PREVAIL, WORK IN A VENTILATION HOOD OR
    WEAR A NIOSH-APPROVED MASK.
Ventilation:LOCAL EXHAUST: RECOMMENDED. MECHANICAL
    (GENERAL):RECOMMENDED. SPECIAL:NO. OTHER:NO.
Protective Gloves:RUBBER.
Eye Protection:CHEMICAL SAFETY GLASSES.
Other Protective Equipment:GOGGLES, LAB COAT, VENTILATION HOOD, PROPER
    GLOVES AND EYE WASH STATION.
Work Hygienic Practices:DO NOT INGEST. REMOVE AND WASH CONTAMINATED
    CLOTHING. AVOID BREATHING DUST OR VAPOR.
Supplemental Safety and Health
ITEM # 39-0865

==================  Physical/Chemical Properties  ==================

HCC:T4
Boiling Pt:=178.C, 352.4F
Melt/Freeze Pt:=238.C, 460.4F
M.P/F.P Text:SUBLIMES
Vapor Pres:760 @178C
Vapor Density:NA
Spec Gravity:1.23
Evaporation Rate & Reference:NA
Solubility in Water:1G/46ML AT 20C
Appearance and Odor:WHITE NEEDLES OR WHITE POWDER; NO ODOR.
Percent Volatiles by Volume:0.5

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZERS, HOT ALKALIES, CHLORINE WATER.
Stability Condition to Avoid:EXCESSIVE TEMPERATURES AND HEAT.
Hazardous Decomposition Products:WHEN HEATED TO DECOMPOSITION, EMITS
    TOXIC FUMES OF NITROUS OXIDES, CARBON MONOXIDE, CARBON DIOXIDE.

===================  Toxicological Information	===================

Toxicological Information:RTECSNO. EV6475000 TOXICITY DATA: ORAL-CHILD
    LDLO:320MG/KG.ORAL-WOMAN LDLO:1000MG/KG,ORAL-INFANT TDLO:
    14700UG/KG. ORAL-MOUSE LD50:127MG/KG.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISCHARGE, TREATMENT OR DISPOSAL MAY BE SUBJECT
    TO FEDERAL, STATE OR LOCAL LAWS. THESE DISPOSAL GUIDELINES ARE
    INTENDED FOR THE DISPOSAL OF CATALOG-SIZE QUANTITIES ONLY. DISPOSE
    OF IN AN APPROVED INCI NERATOR.

===================  MSDS Transport Information  ===================

Transport Information:DOT: POISONOUS SOLIDS, N.O.S. (CAFFEINE), 6.1, UN
    2811.

=======================  Other Information  =======================

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 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
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 particular situation.